Modulatory Role of Simvastatin against Aluminium Chloride-Induced Behavioural and Biochemical Changes in Rats
Table 3
Effect of simvastatin on AlCl3-induced biochemical changes on hippocampus.
Treatment
MDA (nmol/mg of protein)
Nitrite (nmol/mg of protein)
Reduced glutathione (μmol/mg of protein)
Catalase (μmol of H2O2 decomposed/min/mg of protein)
AChE (μmoles of acetylthiocholine iodide hydrolyzed/min/mg of protein)
Normal control
0.091 ± 0.0138
1.64 ± 0.090
0.110 ± 0.0036
22.80 ± 1.57
0.0251 ± 0.0016
Vehicle control
0.091 ± 0.0073
1.87 ± 0.373
0.099 ± 0.0036
23.40 ± 1.71
0.0261 ± 0.0017
AlCl3
0.206 ± 0.0106*
3.86 ± 0.137*
0.053 ± 0.0010*
4.77 ± 0.61*
0.0074 ± 0.0021*
AlCl3 + rivastigmine
0.143 ± 0.0119#
1.95 ± 0.249#
0.084 ± 0.0043#
15.50 ± 1.43#
0.0060 ± 0.0011#
AlCl3 + simvastatin
0.182 ± 0.0114#
1.96 ± 0.435#
0.086 ± 0.0044#
12.11 ± 1.26#
0.0230 ± 0.0016#
Effect of AlCl3 and AlCl3 + treatments on hippocampus (a) MDA, (b) nitrite level, (c) glutathione (GSH) level, (d) catalase activity, and (e) acetylcholinesterase activity. Data are presented as mean ± SEM ( = 8). as compared to control group and as compared to AlCl3 treated group.
