Feasibility and Safety of Continuous and Chronic Bilateral Deep Brain Stimulation of the Medial Forebrain Bundle in the Naïve Sprague-Dawley Rat

Figure 6

Behavioral testing. MFB-HFS did not have any specific effects on the animals’ anxiolytic behavior as measured by the elevated plus maze: stimulated animals performed identical to the controls both before and after stimulation (a). Similarly, the stimulation had no impact on the animals’ performance in the Forced Swim Test, a measure of behavioral despair (b). See text for more detail. closed arm compared to open arm.

(a) Elevated plus maze

(b) Force Swim Test