Amyloid β Enhances Typical Rodent Behavior While It Impairs Contextual Memory Consolidation

Figure 1

Aβ does not affect hippocampal integrity. ((a)–(f)) Representative microphotographs of hippocampal sections obtained from animals injected with vehicle ((a)–(c)) or 400 pmoles of Aβ ((d)–(f)). ((a) and (d)) Panoramic view of the hippocampus (10x). ((b) and (e)) Magnification of the dentate gyrus (40x) from the area enclosed in the squares shown in (a) and (d), respectively. ((c) and (f)) Magnification of the CA1 region (40x) from the area enclosed in the squares shown in (a) and (d), respectively. (g) Quantification of the area (mean ± S.E.M) of the granular cell layer and the pyramidal cell layer from sections of animals injected with vehicle (Ctrl) or 400 pmoles of Aβ ( = 10/group). Note that Aβ injection does not modify hippocampal integrity measured as the granular or pyramidal area.

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