Amyloid β Enhances Typical Rodent Behavior While It Impairs Contextual Memory Consolidation

Figure 2

Aβ induces contextual memory deficits. (a) Training and escape latencies of groups injected into the hippocampus with MF12 (Ctrl) or Aβ (200, 400, and 800 pmoles) and then evaluated in the inhibitory avoidance task. There were no significant differences among the groups in either latency. (b) Retention latencies of Ctrl and Aβ groups measured 48 h after training ( = 6–11 rats/group). Data are presented as medians ± interquartile ranges. versus Ctrl.

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