Review Article

Magnetic Resonance Imaging Studies of Postpartum Depression: An Overview

Table 1


Silverman et al., 2007 [39]BOLD activation (pilot study) (4 PPD) 4–6 weeks from deliveryExposure to emotionally valenced stimuli: activation of R amygdala

Silverman et al., 2011 [40] BOLD activation (6 PPD) 4–6 weeks from deliverySame as above

Moses-Kolko et al., 2010 [41]BOLD activation (14 PPD) within 12 weeks from deliveryExposure to faces and shapes: L dorsomedial prefrontal face-related activity, L amygdala activity in more severe PPD

Moses-Kolko et al., 2011 [42]BOLD activation (12 PPD) avg. 8 weeks from deliveryMonetary reward guessing task: rapid attenuation of ventral striatal activity

Laurent and Ablow, 2012 [43]BOLD activation (11 PPD) 15–18 months from deliveryExposure to own infant’s cry, to other infants’ cry, and to control sound. In depressed mothers no activation for own infant versus control plus activation in caudate, accumbens, and medial thalamic. In less depressed mothers act in L orbitofrontal, dorsal anterior cingular cortex, and medial superior frontal. Only in nondepressed mothers, activation in fusiform gyrus (own versus other infants)

Laurent and Ablow, 2013 [44]BOLD activation (11 PPD) 15–18 months from deliveryExposure to own infant’s distress faces: in more depressed mothers, activation of dorsal anterior cingulate cortex. Exposure to own infant’s joy faces: in depressed mothers, orbitofrontal and insular activity. Exposure to joy-distress faces reduced L prefrontal and insular striatal act

Wang et al., 2011 [47]BOLD resting state (10 PPD) within 16 weeks of delivery activity consistency in cingulate cortex and frontal and parietal lobe activity consistency in temporal and frontal lobe (regional homogeneity (ReHo) analysis)

Deligiannidis et al., 2013 [45]BOLD resting state (9 PPD) within 9 weeks of delivery connectivity with anterior cingulate cortex, amygdalae, hippocampi, and dorsolateral prefrontal cortex

Chase et al., 2014 [46]BOLD resting state (14 PPD) avg. 8 weeks from delivery posterior cingular cortex connectivity with R amygdala

Epperson et al., 2006 [48]MR spectroscopy (9 PPD) within 24 weeks from deliveryTrend to GABA levels in occipital cortex

McEwen et al., 2012 [49]MR spectroscopy (12 PPD) within 12 weeks from delivery glutamate levels in medial prefrontal cortex