Screening Mild and Major Neurocognitive Disorders in Parkinson’s Disease
Table 2
Diagnostic accuracy of screening tests for detecting mild neurocognitive disorder due to Parkinson’s disease.
Diagnostic accuracy
MoCA
ACE
MMSE
MDRS
Estimation
Lower 95% CI
Upper 95% CI
Estimation
Lower 95% CI
Upper 95% CI
Estimation
Lower 95% CI
Upper 95% CI
Estimation
Lower 95% CI
Upper 95% CI
Best cut-off score
23.5
83.5
27.5
139.5
Sensitivity
0.915
0.848
0.958
0.871
0.790
0.930
0.602
0.540
0.714
0.939
0.873
0.977
Specificity
0.831
0.777
0.877
0.797
0.741
0.847
0.706
0.652
0.723
0.670
0.605
0.730
Positive predictive value
0.733
0.653
0.803
0.647
0.561
0.727
0.623
0.534
0.707
0.550
0.472
0.627
Negative predictive value
0.950
0.911
0.976
0.936
0.892
0.965
0.650
0.598
0.793
0.962
0.920
0.986
Diagnostic accuracy
0.859
0.818
0.894
0.820
0.774
0.859
0.671
0.624
0.712
0.751
0.700
0.797
Likelihood ratio of a positive test
5.417
4.047
7.250
4.302
3.305
5.599
2.575
1.804
3.125
2.843
2.349
3.440
Likelihood ratio of a negative test
0.103
0.057
0.187
0.161
0.097
0.269
0.312
0.259
0.484
0.091
0.041
0.198
Mild neurocognitive disorder because Parkinson’s disease was defined by the Diagnostic and Statistical Manual of Mental Disorders 5th edition criteria. ACE: Addenbrooke’s Cognitive Examination; CI: confidence interval; MDRS: Mattis Dementia Rating Scale; MMSE: Mini Mental State Examination; MoCA: Montreal Cognitive Assessment.
