Review Article

Pain in Neurodegenerative Disease: Current Knowledge and Future Perspectives

Table 3

Summary of studies on the prevalence and features of pain among patients with amyotrophic lateral sclerosis.

Study designNumber of patients and controlsAssessment methodsFrequency of painFeature and location of pain

Ganzini et al. [18]Observational 100 patientsInterview to patients and caregivers19% reporting moderate to severe painNot reported

Jensen et al. [19]Observational193 patients with neuromuscular disease
(30 ALS)
Neuropathic pain scale, Brief Pain Inventory, quality of life (SF-36)60% of ALS patients “Deep,” “tiring,” “sharp,” and “dull” 
Localized in the back, leg, shoulder, and neck (total of patients with neuromuscular disease)

Ho et al. [20]Retrospective193 patientsStandard medical records23%Shoulder pain

Chiò et al. [21]Case control160 patientsBrief Pain Inventory56.9%Pain more frequent in the extremities

Pagnini et al. [22]Observational40 patientsItalian Pain Questionnaire, McGill Quality of Life Questionnaire 51.2%“Nagging,”
“sore,” “periodic,”
“annoying,” “exhausting,” “enduring,”
“debilitating,” and “worrying”

Rivera et al. [23]Observational63Neuropathic pain scale50%Neuropathic pain

Pizzimenti et al. [24]Observational36Neuropathic Pain Symptom Inventory
(2 items)
71%Localized in scapular-humeral area and lower limb

Wallace et al. [25]Case control42Brief Pain Inventory
PainDETECT Questionnaire
85%Nonneuropathic:
cramping, aching, tiring, sharp, and tender

Hanisch et al. [26]Case control46Brief Pain Inventory78%Cramps

Moisset et al. [27]Observational93DN4 questionnaire66%9% neuropathic pain