Spatial Navigation Impairment Is Associated with Alterations in Subcortical Intrinsic Activity in Mild Cognitive Impairment: A Resting-State fMRI Study

Figure 1

The illustration of the SN tasks. The start point was a red solid circle, the goal was a purple hollow circle, and two orientation points for allocentric reference were a green bar and a set of yellow points. (A) All the points were shown to participate in Allo-Ego mixed task (upper row), start point and goal were shown in Ego task (middle row), and orientation points and goal were shown in Allo task (bottom row). (B) After proper instruction and training trials, the goal is hidden, and then the whole arena rotates with a random angle clockwise or anticlockwise to a new position. (C) The participant is required to draw the route from the start point to the goal on the screen using the mouse. The distance between the participants’ chosen goal and correct goal is recorded (the total distance error).