Spatial Navigation Impairment Is Associated with Alterations in Subcortical Intrinsic Activity in Mild Cognitive Impairment: A Resting-State fMRI Study

Table 1

Subjects’ characteristics; mean (SD).

	NC ()	MCI ()	value/χ^2	value
MOCA	27.8 ± 2.3	22.0 ± 2.6	7.74	10^−9
MMSE	29.0 ± 1.0	26.2 ± 2.7	4.46	10^−4
Allo-Ego navigation error	34.6 ± 16.9	48.7 ± 45.0	−1.35	0.19
Allocentric navigation error	37.0 ± 23.7	51.1 ± 35.0	−0.47	0.64
Egocentric navigation error	44.2 ± 17.2	48.5 ± 40.0	−2.12	0.04
Age (y)	70.7 ± 10.9	64.3 ± 11.1	−1.91	0.06
Education (y)	15.2 ± 2.3	11.6 ± 4.2	−3.48	0.001
Gender (M/F)	7/14	12/10	16.19	0.001
Scanner (T/I)	13/8	11/11	3.83	0.05

value is from chi-square test for the between-group differences on scanner and gender, and two-sample t-test for continuous variables; positive value indicates NC > MCI. The value is the total distance error in corresponding SN tasks. Note that the higher value for SN distance error indicates a greater total error within a given task. T = Achieva TX; I = Ingenia scanner type.