The Effect of Gentle Handling on Depressive-Like Behavior in Adult Male Mice: Considerations for Human and Rodent Interactions in the Laboratory

Figure 1

Duration immobile by handling group (gentle, aggressive, and control). The results demonstrate significant differences () between the gently handled mice (median = 42.50 s) compared to the aggressively handled mice (median = 170.50 s) and marginally significant differences between the gently handled mice and control mice (median = 106.00 s). No differences were found between the aggressively handled and control mice. Box plots illustrate individual data points (solid dots), lower and upper quartiles (upper and lower sides of box plot), median (dark, middle bar), and lowest and highest values (whiskers).