Gait and Conditioned Fear Impairments in a Mouse Model of Comorbid TBI and PTSD

Figure 3

Impaired fear recall in TBI + PTSD mice following contextual fear conditioning. (a) Experimental design and fear conditioning procedure. (b) Contextual fear acquisition. There were no group differences in fear learning. (c) Context generalization. PTSD mice froze significantly more in context B compared to both control () and TBI only mice (). (d) Contextual fear recall. TBI + PTSD mice showed deficits in contextual fear recall relative to controls (). Error bars ± SEM, . ITI = intertrial interval.

(a)

(b)

(c)

(d)