The Pathogenesis of Necroptosis-Dependent Signaling Pathway in Cerebral Ischemic Disease

Figure 1

Two classic pathways of necroptosis. One of the classic pathways is RIP3 binding to RIP1 to form procedural necrosis complex II, which in turn binds to MLKL and mediates necroptosis of the mitochondrial pathway. The other is RIP1 binding to AIF, which translocated into the nucleus and mediates necroptosis of the nuclear pathway.