Risk Factors for the Progression of Mild Cognitive Impairment in Different Types of Neurodegenerative Disorders

Table 1

Univariate analysis of clinical characteristics in 279 MCI patients who remained stationary course or progressed to dementia.

	Stable MCI	Dementia	value
	(percentage)	(percentage)
Etiology	AD 98 (56)	AD 65 (62.5)	0.268
	VaD 42 (24)	VaD 26 (25)
	LBD 35 (20)	LBD 13 (12.5)
Age of onset	70.9	74.7	<0.001
Female	100 (57.1)	48 (46.2)	0.098
Education	6.9	7.3	0.425
CDR-SB	2.20	2.96	<0.001
MMSE	24.5	23.3	0.004
Hypertension	101 (57.7)	63 (60.6)	0.954
DM	51 (29.1)	38 (36.5)	0.373
Dyslipidemia	90 (51.4)	39 (37.5)	0.021
Liver disease	24 (13.7)	19 (18.3)	0.279
Renal disease	20 (11.4)	14 (13.5)	0.844
Gastrointestinal disease	82 (46.9)	50 (48.1)	0.942
Anemia	10 (5.7)	7 (6.7)	0.918
Heart disease	73 (41.7)	47 (45.2)	0.894
Stroke	43 (24.6)	25 (24)	1.000
Depression	26 (14.9)	25 (24)	0.065
Antidementia agents	61 (34.9)	69 (66.3)	<0.001
Hypnotic agents	61 (34.9)	49 (47.1)	0.064
Polypharmacy	103 (58.9)	69 (67.0)	0.314

AD: Alzheimer’s disease; VaD: vascular dementia; LBD: Lewy body diseases; MMSE: Mini-Mental State Examination; CDR-SB: Clinical Dementia Rating-Sum of Boxes; DM: diabetes mellitus. Remark: antidementia agents: acetylcholinesterase inhibitors and memantine. Hypnotic agents: benzodiazepines and nonbenzodiazepine hypnotics.