Efficacy and Safety of Intravenous Thrombolysis in Patients with Unknown Onset Stroke: A Meta-Analysis

Table 3

Overall and subgroup meta-analysis of the included studies.

				Study heterogeneity
Outcomes	No.	OR [95% CI]			df	(%)	- test
Overall analysis
90-day good outcome	7	1.60 [1.23, 2.08]	0.0005	4.39	6	0	0.62
Discharge good outcome	1	1.22 [0.63, 2.37]	0.55	NA	NA	NA	NA
90-day mortality	6	3.07 [0.78, 12.13]	0.11	14.11	4	72	0.007
By discharge mortality	1	1.12 [0.22, 5.75]	0.89	NA	NA	NA	NA
ICH	4	2.06 [0.35, 12.04]	0.42	7.38	3	59	0.06
sICH	7	1.73 [0.98, 3.05]	0.06	1.29	5	0	0.94
Subgroup analysis
MRI
90-day good outcome	2	1.57 [1.15, 2.15]	0.005	0.05	1	0	0.82
90-day mortality	1	3.36 [0.91, 12.36]	0.07	NA	NA	NA	NA
sICH	1	1.63 [0.82, 3.27]	0.17	NA	NA	NA	NA
CT
90-day good outcome	3	1.68 [0.93, 3.01]	0.08	1.88	2	0	0.39
90-day mortality	3	1.30 [0.17, 10.18]	0.8	5.82	2	83	0.02
ICH	3	1.41 [0.17, 11.49]	0.75	6.46	2	69	0.04
sICH	3	1.56 [0.50, 4.84]	0.44	0.68	2	0	0.71
MRI+CT
90-day good outcome	2	1.47 [0.34, 6.30]	0.61	2.44	1	59	0.12
90-day mortality	2	16.25 [1.94, 136.20]	0.01	0.05	1	0	0.82
ICH	1	11.21 [0.42, 297.84]	0.15	NA	NA	NA	NA
sICH	2	3.72 [0.18, 75.14]	0.39	NA	NA	NA	NA

OR: odds ratio; : percentage; NA: not applicable; ICH: intracerebral hemorrhage; sICH: symptomatic ICH; MRI: magnetic resonance imaging; CT: computed tomography.