NPM1/B23: A Multifunctional Chaperone in Ribosome Biogenesis and Chromatin Remodeling
Figure 1
Structure of NPM1. (a) Domain representation of human NPM1, NPM2 and NPM3 proteins. Acidic patches (“A”) are indicated. (HD: heterodimerization domain, DBD: DNA binding domain, NoLS: nucleolar localization motif). (b) Pentamer structure of Xenopus laevis xNPM1/NO38 (PDB ID: 1XE0) as visualized in Jalview PDB viewer. (c) Two pentamers of human NPM1 (PDB ID: 2P1B) stacked in a decameric configuration. (d) Sequence alignment of the core region from different NPM1 proteins and NPM-like proteins. Clustal W was used for alignment and further editing was done with help of Chromas alignment software. The structurally important “AKDE” and “GSGP” loops are indicated in the figure as well as the location of conserved L42 and L102 residues (reference to human NPM1). Hs: Homo sapiens; Mm: Mus musculus; Rn: Rattus norvegicus; Dr: Danio rerio; Gg: Gallus gallus; Xl: Xenopus laevis; Dm: Drosophila melanogaster; Lp: Lytechinus pictus (sea urchin); Ap: Asterina pectinifera (star fish).
