Review Article

NPM1/B23: A Multifunctional Chaperone in Ribosome Biogenesis and Chromatin Remodeling

Table 1

NPM1 binding proteins.

DNA replication, transcription, and repair
 MYC [59]; APE1/Ref-1 [60]; NFKB1 [61]; AR [62]; MIZ1 [63]; AP2 [64]; HEXIM1 [65]; YY1 [66]; CBF-A [67]; IRF1 [68];
 MNDA [69]; GCN5 [70]; Histones [37]; C/EBP [71]; Tpt1 [72]; DOT1L [73]

Cell cycle control
 p53 [74]; ARF [75]; MDM2 [76]; pRB [77]; p21 [78]; GADD45A [79]

Ribosome biogenesis
 EBP1 [80]; SENP3 and SENP5 [81]; RPL5 [43]; RPS9 [82]; RPL23 [63]; Nucleolin [83]; p120 [50]; NPM3 [25]; USP36 [84];
 Nucleostemin [85]; PES1 [86]; TTF1 [87]; FRGY2a/YB1 [88]; NSUN2 [89]

Viral replication
 Human T-cell lymphotropic virus Rex [48]
 HIV Rev and Tat proteins [47]
 Hepatitis delta virus antigens [90]
 Hepatitis B virus core protein [91]
 Mouse mammary tumor virus p14 env-related protein [92]
 Hepatitis C virus core [93]
 Japanese encephalitis virus core protein [94]
 Adenovirus basic core protein [95]

Apoptosis
 Bax [96]; PARP-1 and PARP-2 [97]; PIP3 [98]; GAGE [99]

Stability and splicing of mRNA
 hnRNPU [100]; hnRNPA1 [100]; NSP 5a3a [101]

Protein modification, synthesis, and degradation
 PKR [102]; BRCA1-BARD1 [103]; AKT [104]; Fbw7γ [105]; HLJ1 [106]

Mitotic spindle, cytoskeleton, and centromeres
 CRM1 [44]; RPGR and RPGRIP1 [107]; Eg5 [108]; Plk2 [109]; CTCF [110]