Water Chreodes and the Mechanisms of Ligand Diffusion, General Anesthesia, and Sleep

Table 1

Hydropathic states of amino acid side chains.

Amino Acid	Hydrophobicity^a
Arg	−1.01
Lys	−0.99
Asp	−0.77
Glu	−0.64
Asn	−0.60
Gln	−0.22
Ser	−0.04
Gly	0.00
His	0.13
Thr	0.26
Ala	0.31
Tyr	0.96
Val	1.22
Met	1.23
Cys	1.54
Leu	1.70
Phe	1,79
Ile	1,80
Trp	2.25

^aPi values calculated: J. Fauchere, M. Charton, L. Kier, A Verloop, and V. Pliska. Amino acid side chain parameters for correlation studies in biology and pharmacology. Int. J. Protein Res. 32, 269–278 [1988]. The negative values are hydrophilic; the positive values are hydrophobic.