Research Article

The Increased Activity of Liver Lysosomal Lipase in Nonalcoholic Fatty Liver Disease Contributes to the Development of Hepatic Insulin Resistance

Figure 1

The effect of HFD on the LIPA activity measured as FFA release from artificial substrate (3H-triolein). (a) Homogenate; (b) dense lysosomes; (c) light lysosomes. The lipase activity was measured as the release of fatty acids at pH  = 4.5 from 3H-triolein. Open bars = fasted animals; hatched bars = fed animals. + + 𝑃 < 0 . 0 1 fed versus fasted; # # 𝑃 < 0 . 0 1 HFD fed versus SD fed.
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135723.fig.001b
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