The Increased Activity of Liver Lysosomal Lipase in Nonalcoholic Fatty Liver Disease Contributes to the Development of Hepatic Insulin Resistance
Figure 1
The effect of HFD on the LIPA activity measured as FFA release from artificial substrate (3H-triolein). (a) Homogenate; (b) dense lysosomes; (c) light lysosomes. The lipase activity was measured as the release of fatty acids at pH = 4.5 from 3H-triolein. Open bars = fasted animals; hatched bars = fed animals. fed versus fasted; HFD fed versus SD fed.