Review Article
Mitotic Kinases and p53 Signaling
Table 1
Mitotic kinases-mediated p53 phosphorylation and the possible consequences.
| Mitotic kinases | Phosphorylation sites | Outcome | References |
| Aurora kinases | | | | Aurora A | Ser-215 | Inhibition of DNA binding and transcriptional activity | [85] | Ser-315 | Protein destabilization | [55] | Aurora B | Ser-183 | Unknown |
[46] | Ser-269/Thr284 | Inhibition of transcriptional activity | Aurora C | | Unknown | |
| Polo-like kinases | | | | Plk1 | Unknown | Inhibition of transcriptional and proapoptotic activity | [146] | Plk2 | | Unknown | | Plk3 | Ser-20 | Protein stabilization | [169] | Plk4 | Unknown | Possibly affecting protein stabilization and transcriptional activation | [178] | Plk5 | | Unknown | |
| SAC kinases | | | | Bub1 | Ser-37 | Possibly inducing cellular senescence | [193] | Mps1 | Thr-18 | p53 stabilization |
[58] | p53-dependent postmitotic checkpoint activation | BubR1 | Unknown | p53 stabilization | [59] |
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