371415.fig.008a
(a)
371415.fig.008b
(b)
371415.fig.008c
(c)
371415.fig.008d
(d)
371415.fig.008e
(e)
Figure 8: Representative amplitude-normalized calcium transients of Pig ((a)–(c)) and Mouse (d) left-ventricular myocytes (0.5 Hz, field stimulus denoted by arrow). Calcium transients from Pig exhibited multiple waveforms, including normal recovery from the transient peak (a, 2 of 14 cells), recovery with a marked shoulder ((b), 8 of 14 cells), and recovery with a secondary increase in calcium (c, 4 of 14 cells). (d) Mouse transients consistently exhibited a rapid transient recovery ( ). (e) Overlay of transients shown in (b) and (d) illustrating the distinct transient kinetics between pig (gray) and mouse (black) myocytes.