Review Article

Implication of Mitochondrial Cytoprotection in Human Islet Isolation and Transplantation

Table 1

Oxygen carriers used in pancreas organ preservation and islet isolation.

Oxygen carriersBenefitsLimitationReferences

PFC(i) Prevention of ischemia injury
(ii) Improvement of islet yield and quality
(iii) Inhibition of apoptosis by mitochondrial
protection via oxygen loading
(iv) Preservation of islet cell energetic status
(v) Low islet oxidative stress
(vi) Better in vivo islet graft function
(i) Inconsistent results despite several large-scale
  human trials
(ii) May only be useful for marginal donors with
  prolonged ischemia
(iii) Limited oxygen penetration into pancreas
(iv) Poor water solubility
(v) Indeterminate biosafety
[2242]

PFD(i) Preservation of islet ATP levels(i) Only tested in animal model
(ii) Impairment of insulin secretion
[43]

poly SFH-P(i) Improvement of islet yield and quality
(ii) Preservation of mitochondrial integrity
(iii) No increase in oxidative stress
(iv) Better in vivo islet graft function
(v) High oxygen tension with oxygen saturation
  curve similar to RBCs
(i) Only in rodent model
(ii) Warm-ischemia model used may not be
applicable in a cold-ischemia model
(iii) Product discontinued
[44]