At the Start of the Sarcomere: A Previously Unrecognized Role for Myosin Chaperones and Associated Proteins during Early Myofibrillogenesis

Figure 2

Schematic diagram of the sarcomere and costamere protein complexes of striated muscle cells. Major components of the mature sarcomere and costamere are shown, along with the cytoskeletal and motor filament systems, in context with the sarcolemma and organelles of syncytial myocytes. Known chaperone or cochaperone molecules are shown in bold, along with their substrates. Arrows indicate regions where chaperone-mediated protein folding is essential to incorporate polymeric filament proteins. Modified from Sparrow and Schock [17], additional artwork by A. Pete.