Review Article

At the Start of the Sarcomere: A Previously Unrecognized Role for Myosin Chaperones and Associated Proteins during Early Myofibrillogenesis

Figure 4

Proposed model of roles for Unc45b/nonmuscle myosin during early myofibrillogenesis. (a) Merged protein model of Unc-45b from the X-ray crystal structure of Drosophila UNC-45 and the solved NMR structure of the human Unc45a TPR domain (protein database ID 2DBA), showing the known active domains. Proposed functions of each section of the protein are indicated. Modified from Lee et al. [139]. (b) Flowchart of myofibrillogenesis, listing the stages where there is significant evidence to hypothesize the involvement of UNC-45. Events that likely involve UNC-45 chaperone function at each stage of myogenesis are noted, and probable cofactors for UNC-45 are indicated in red.
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