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Biochemistry Research International
Volume 2012 (2012), Article ID 738274, 5 pages
http://dx.doi.org/10.1155/2012/738274
Review Article

Endometrial Cancer and Hypermethylation: Regulation of DNA and MicroRNA by Epigenetics

Department of Obstetrics and Gynecology, Keio University School of Medicine, Shinanomachi 35 Shinjuku-ku, Tokyo 160-8582, Japan

Received 31 October 2011; Accepted 2 February 2012

Academic Editor: Yong-yu Liu

Copyright © 2012 Kouji Banno et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Esteller, “Epigenetics in cancer,” New England Journal of Medicine, vol. 358, no. 11, pp. 1148–1159, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  2. S. A. Wajed, P. W. Laird, and T. R. DeMeester, “DNA methylation: an alternative pathway to cancer,” Annals of Surgery, vol. 234, no. 1, pp. 10–20, 2001. View at Publisher · View at Google Scholar · View at Scopus
  3. Y. Muraki, K. Banno, M. Yanokura et al., “Epigenetic DNA hypermethylation: clinical applications in endometrial cancer,” Oncology Reports, vol. 22, no. 5, pp. 967–972, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Velasco, J. Pallares, M. Santacana et al., “Promoter hypermethylation and expression of sprouty 2 in endometrial carcinoma,” Human Pathology, vol. 42, no. 2, pp. 185–193, 2011. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  5. J. Pallares, A. Velasco, N. Eritja et al., “Promoter hypermethylation and reduced expression of RASSF1A are frequent molecular alterations of endometrial carcinoma,” Modern Pathology, vol. 21, no. 6, pp. 691–699, 2008.
  6. H. S. Kang, T. Baba, M. Mandai et al., “GPR54 is a target for suppression of metastasis in endometrial cancer,” Molecular Cancer Therapeutics, vol. 10, no. 4, pp. 580–590, 2011. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  7. T. Z. Yi, J. Guo, L. Zhou et al., “Prognostic value of E-cadherin expression and CDH1 promoter methylation in patients with endometrial carcinoma,” Cancer Investigation, vol. 29, no. 1, pp. 86–92, 2011. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  8. S. B. Dewdney, B. J. Rimel, P. H. Thaker et al., “Aberrant methylation of the X-linked ribosomal S6 kinase RPS6KA6 (RSK4) in endometrial cancers,” Clinical Cancer Research, vol. 17, no. 8, pp. 2120–2129, 2011. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  9. A. Ignatov, J. Bischoff, T. Ignatov et al., “APC promoter hypermethylation is an early event in endometrial tumorigenesis,” Cancer Science, vol. 101, no. 2, pp. 321–327, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  10. A. Satoh, M. Toyota, F. Itoh et al., “Epigenetic inactivation of CHFR and sensitivity to microtubule inhibitors in gastric cancer,” Cancer Research, vol. 63, no. 24, pp. 8606–8613, 2003. View at Scopus
  11. X. Wang, Y. Yang, C. Xu et al., “CHFR suppression by hypermethylation sensitizes endometrial cancer cells to paclitaxel,” International Journal of Gynecological Cancer, vol. 21, no. 6, pp. 996–1003, 2011.
  12. T. L. Lo, P. Yusoff, C. W. Fong et al., “The Ras/mitogen-activated protein kinase pathway inhibitor and likely tumor suppressor proteins, sprouty 1 and sprouty 2 are deregulated in breast cancer,” Cancer Research, vol. 64, no. 17, pp. 6127–6136, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  13. H. Sutterlüty, C. E. Mayer, U. Setinek et al., “Down-regulation of Sprouty2 in non-small cell lung cancer contributes to tumor malignancy via extracellular signal-regulated kinase pathway-dependent and -independent mechanisms,” Molecular Cancer Research, vol. 5, no. 5, pp. 509–520, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  14. C. W. Fong, M. S. Chua, A. B. McKie et al., “Sprouty 2, an inhibitor of mitogen-activated protein kinase signaling, is down-regulated in hepatocellular carcinoma,” Cancer Research, vol. 66, no. 4, pp. 2048–2058, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  15. R. Holliday, “The inheritance of epigenetic defects,” Science, vol. 238, no. 4824, pp. 163–170, 1987. View at Scopus
  16. P. N. Schofield, J. A. Joyce, W. K. Lam et al., “Genomic imprinting and cancer; new paradigms in the genetics of neoplasia,” Toxicology Letters, vol. 120, no. 1–3, pp. 151–160, 2001. View at Publisher · View at Google Scholar · View at Scopus
  17. P. Peltomäki, “Lynch syndrome genes,” Familial Cancer, vol. 4, no. 3, pp. 227–232, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  18. E. Kondo, T. Furukawa, K. Yoshinaga et al., “Not hMSH2 but hMLH1 is frequently silenced by hypermethylation in endometrial cancer but rarely silenced in pancreatic cancer with microsatellite instability.,” International journal of oncology, vol. 17, no. 3, pp. 535–541, 2000. View at Scopus
  19. C. M. Suter, D. I. K. Martin, and R. L. Ward, “Germline epimutation of MLH1 in individuals with multiple cancers,” Nature Genetics, vol. 36, no. 5, pp. 497–501, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  20. M. P. Hitchins, J. J. L. Wong, G. Suthers et al., “Inheritance of a cancer-associated MLH1 germ-line epimutation,” New England Journal of Medicine, vol. 356, no. 7, pp. 697–705, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  21. A. Goel, T. P. Nguyen, H. C. E. Leung et al., “De novo constitutional MLH1 epimutations confer early-onset colorectal cancer in two new sporadic Lynch syndrome cases, with derivation of the epimutation on the paternal allele in one,” International Journal of Cancer, vol. 128, no. 4, pp. 869–878, 2011. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  22. T. L. Chan, S. T. Yuen, C. K. Kong et al., “Heritable germline epimutation of MSH2 in a family with hereditary nonpolyposis colorectal cancer,” Nature Genetics, vol. 38, no. 10, pp. 1178–1183, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  23. B. T. F. van der Gun, L. J. Melchers, M. H. Ruiters, L. F. M. H. de Leij, P. M. J. McLaughlin, and M. G. Rots, “EpCAM in carcinogenesis: the good, the bad or the ugly,” Carcinogenesis, vol. 31, no. 11, pp. 1913–1921, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  24. M. J. L. Ligtenberg, R. P. Kuiper, T. L. Chan et al., “Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3′ exons of TACSTD1,” Nature Genetics, vol. 41, no. 1, pp. 112–117, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  25. K. I. Kozaki, I. Imoto, S. Mogi, K. Omura, and J. Inazawa, “Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer,” Cancer Research, vol. 68, no. 7, pp. 2094–2105, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  26. M. Furuta, K. I. Kozaki, S. Tanaka, S. Arii, I. Imoto, and J. Inazawa, “miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma,” Carcinogenesis, vol. 31, no. 5, pp. 766–776, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  27. J. Pierson, B. Hostager, R. Fan, and R. Vibhakar, “Regulation of cyclin dependent kinase 6 by microRNA 124 in medulloblastoma,” Journal of Neuro-Oncology, vol. 90, no. 1, pp. 1–7, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  28. Y. Saito, J. M. Friedman, Y. Chihara, G. Egger, J. C. Chuang, and G. Liang, “Epigenetic therapy upregulates the tumor suppressor microRNA-126 and its host gene EGFL7 in human cancer cells,” Biochemical and Biophysical Research Communications, vol. 379, no. 3, pp. 726–731, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  29. H. Nakano, T. Miyazawa, K. Kinoshita, Y. Yamada, and T. Yoshida, “Functional screening identifies a microRNA, miR-491 that induces apoptosis by targeting Bcl-XLin colorectal cancer cells,” International Journal of Cancer, vol. 127, no. 5, pp. 1072–1080, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  30. Y. W. Huang, J. C. Liu, D. E. Deatherage et al., “Epigenetic repression of microRNA-129-2 leads to overexpression of SOX4 oncogene in endometrial cancer,” Cancer Research, vol. 69, no. 23, pp. 9038–9046, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  31. T. Tsuruta, K. I. Kozaki, A. Uesugi et al., “miR-152 is a tumor suppressor microRNA that is silenced by DNA hypermethylation in endometrial cancer,” Cancer Research, vol. 71, no. 20, pp. 6450–6462, 2011.
  32. D. J. P. M. Stumpel, D. Schotte, E. A. M. Lange-Turenhout et al., “Hypermethylation of specific microRNA genes in MLL-rearranged infant acute lymphoblastic leukemia: major matters at a micro scale,” Leukemia, vol. 25, no. 3, pp. 429–439, 2011. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  33. Y. Chen, Y. Song, Z. Wang et al., “Altered expression of MiR-148a and MiR-152 in gastrointestinal cancers and its clinical significance,” Journal of Gastrointestinal Surgery, vol. 14, no. 7, pp. 1170–1179, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  34. C. Braconi, N. Huang, and T. Patel, “Microrna-dependent regulation of DNA methyltransferase-1 and tumor suppressor gene expression by interleukin-6 in human malignant cholangiocytes,” Hepatology, vol. 51, no. 3, pp. 881–890, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  35. H. Z. Chen, S. Y. Tsai, and G. Leone, “Emerging roles of E2Fs in cancer: an exit from cell cycle control,” Nature Reviews Cancer, vol. 9, no. 11, pp. 785–797, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  36. L. Trusolino, A. Bertotti, and P. M. Comoglio, “MET signalling: principles and functions in development, organ regeneration and cancer,” Nature Reviews Molecular Cell Biology, vol. 11, no. 12, pp. 834–848, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  37. D. Roulin, Y. Cerantola, A. Dormond-Meuwly, N. Demartines, and O. Dormond, “Targeting mTORC2 inhibits colon cancer cell proliferation in vitro and tumor formation in vivo,” Molecular Cancer, vol. 9, article no. 57, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  38. D. A. Guertin, D. M. Stevens, M. Saitoh et al., “mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice,” Cancer Cell, vol. 15, no. 2, pp. 148–159, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus