Cardiomyopathy Classification: Ongoing Debate in the Genomics Era

Table 1

Summary of AHA 2006 classification [1].

Primary cardiomyopathies	Secondary cardiomyopathies
Genetic (hypertrophic cardiomyopathy; conduction abnormalities: prolonged QT syndrome; Brugada syndrome)	Infiltrative (amyloidosis and Gaucher disease)
Mixed (dilated cardiomyopathy; restrictive cardiomyopathy)	Storage (haemochromatosis and Fabry’s disease)
Acquired (inflammatory myocarditis, peripartum, stress cardiomyopathy—“broken heart syndrome” or tako-tsubo)	Toxicity (drugs, alcohol, heavy metals, and chemicals/chemotherapy)
	Inflammatory (sarcoidosis) endocrine (diabetes mellitus; thyroid disorders; hyperparathyroidism), cardiofacial (Noonan syndrome, lentiginosis) neuromuscular/neurological, nutritional deficiencies, and autoimmune and collagen disorders