Review Article
Cardiomyopathy Classification: Ongoing Debate in the Genomics Era
Table 3
Genes associated with dilated cardiomyopathy.
| Gene | Protein | Function | Reference |
| Autosomal dominant | ACTC | Cardiac actin | Sarcomere protein | [19] | DES | Desmin | Dystrophin-associated glycoprotein complex | [20] | SGCD | δ-Sarcoglycan | Dystrophin-associated glycoprotein complex | [21] | MYH7 | β-Myosin heavy chain | Sarcomere protein | [22, 23] | TNNT2 | Cardiac troponin T | Sarcomere protein | [22, 24, 25] | TPM1 | α-Tropomyosin | Sarcomere protein | [26] | TTN | Titin | Sarcomere structure | [27] | VCL | Metavinculin | Intercalated discs | [28] | MYBPC | Myosin-binding protein C | Sarcomere protein | [23] | MLP/CSRP3 | Muscle LIM protein | Z discs | [29] | ACTN2 | α-Actinin-2 | Sarcomere structure | [30] | MYH6 | α-Myosin heavy chain | Sarcomere protein | [31] | ABCC | SUR2A | Cardiac K channel | [32] | LMNA | Lamin A/C | Nuclear membrane protein | [33] | PLN | Phospholamban | Sarcoplasmic reticulum Ca regulator | [34, 35] | ZASP/LBD3 | Cypher | Cytoskeletal assembly | [36] |
| X linked | DMD | Dystrophin | Dystrophin-associated glycoprotein complex | [37, 38] | TAZ/G4.5 | Tafazzin | [39, 40] |
| Recessive | TNNI3 | Troponin I | Sarcomere protein | [41] |
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