Table 4: Genes associated with ARVD.

LocusGeneProteinFunctionReferences

ARVD1TGFB3Transforming growth factor β3Cell signalling[42, 43]
ARVD2RYR2Ryanodine receptor 2Sarcoplasmic reticulum calcium channel[44, 45]
ARVD3Not known[46]
ARVD4Not known[47]
ARVD5LAMR1Extracellular matrix glycoproteinCell signalling, adhesion, and migration[48, 49]
ARVD6PTPLAProtein-tyrosine phosphatase-like member AFatty acid synthesis[50, 51]
ARVD7DES; ZASPDesmosomal protein; PDZ domain proteinDystrophin-associated glycoprotein complex, andCytoskeletal assembly[52, 53]
ARVD8DSPDesmoplakinAnchoring of intermediate filaments[53, 54]
ARVD9PKP2Plakophilin 2Cell adhesion[55, 56]
ARVD10DSG2Desmoglein 2Calcium-binding transmembrane glycoprotein[57, 58]
ARVD11DSC2Desmocollin 2Calcium-dependent glycoprotein[59, 60]