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Biochemistry Research International
Volume 2012 (2012), Article ID 808934, 5 pages
http://dx.doi.org/10.1155/2012/808934
Review Article

Transcriptional Regulation of the p53 Tumor Suppressor Gene in S-Phase of the Cell-Cycle and the Cellular Response to DNA Damage

1Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA
2Departamento de Genética, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil
3Department of Hematology-Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA

Received 3 April 2012; Revised 20 June 2012; Accepted 21 June 2012

Academic Editor: Rolf J. Craven

Copyright © 2012 David Reisman et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The p53 tumor suppressor induces the transcription of genes that negatively regulate progression of the cell cycle in response to DNA damage or other cellular stressors and thus participates in maintaining genome stability. Numerous studies have demonstrated that p53 transcription is activated before or during early S-phase in cells progressing from G0/G1 into S-phase through the combined action of two DNA-binding factors RBP-Jκ and C/EBPβ-2. Here, we review evidence that this induction occurs to provide available p53 mRNA in order to prepare the cell for DNA damage in S-phase, this ensuring a rapid response to DNA damage before exiting this stage of the cell cycle.