- About this Journal ·
- Abstracting and Indexing ·
- Aims and Scope ·
- Article Processing Charges ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Recently Accepted Articles ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
Biochemistry Research International
Volume 2012 (2012), Article ID 808934, 5 pages
Transcriptional Regulation of the p53 Tumor Suppressor Gene in S-Phase of the Cell-Cycle and the Cellular Response to DNA Damage
1Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA
2Departamento de Genética, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil
3Department of Hematology-Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA
Received 3 April 2012; Revised 20 June 2012; Accepted 21 June 2012
Academic Editor: Rolf J. Craven
Copyright © 2012 David Reisman et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- M. Oren and J. Bartek, “The sunny side of p53,” Cell, vol. 128, no. 5, pp. 826–828, 2007.
- K. H. Vousden and C. Prives, “Blinded by the light: the growing complexity of p53,” Cell, vol. 137, no. 3, pp. 413–431, 2009.
- R. Beckerman and C. Prives, “Transcriptional regulation by p53,” Cold Spring Harbor Perspectives in Biology, vol. 2, no. 8, 2010.
- F. Toledo and G. M. Wahl, “Regulating the p53 pathway: in vitro hypotheses, in vivo veritas,” Nature Reviews Cancer, vol. 6, no. 12, pp. 909–923, 2006.
- D. W. C. Li, J. P. Liu, P. C. Schmid et al., “Protein serine/threonine phosphatase-1 dephosphorylates p53 at Ser-15 and Ser-37 to modulate its transcriptional and apoptotic activities,” Oncogene, vol. 25, no. 21, pp. 3006–3022, 2006.
- R. Pedeux, S. Sengupta, J. C. Shen et al., “ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation,” Molecular and Cellular Biology, vol. 25, no. 15, pp. 6639–6648, 2005.
- H. Zheng, H. You, X. Z. Zhou et al., “The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response,” Nature, vol. 419, no. 6909, pp. 849–853, 2002.
- P. Zacchi, M. Gostissa, T. Uchida et al., “The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults,” Nature, vol. 419, no. 6909, pp. 853–857, 2002.
- J. P. Kruse and W. Gu, “SnapShot: p53 posttranslational modifications,” Cell, vol. 133, no. 5, pp. 930–e1, 2008.
- A. Olsson, C. Manzl, A. Strasser, and A. Villunger, “How important are post-translational modifications in p53 for selectivity in target-gene transcription and tumour suppression?” Cell Death and Differentiation, vol. 14, no. 9, pp. 1561–1575, 2007.
- K. H. Vousden and X. Lu, “Live or let die: the cell's response to p53,” Nature Reviews Cancer, vol. 2, no. 8, pp. 594–604, 2002.
- N. E. Sharpless and R. A. DePinho, “p53: good cop/bad cop,” Cell, vol. 110, no. 1, pp. 9–12, 2002.
- K. H. Vousden and C. Prives, “P53 and prognosis: new insights and further complexity,” Cell, vol. 120, no. 1, pp. 7–10, 2005.
- M. B. Kastan and E. Berkovich, “p53: a two-faced cancer gene,” Nature Cell Biology, vol. 9, no. 5, pp. 489–491, 2007.
- L. Weisz, M. Oren, and V. Rotter, “Transcription regulation by mutant p53,” Oncogene, vol. 26, no. 15, pp. 2202–2211, 2007.
- S. Strano, S. Dell'Orso, S. Di Agostino, G. Fontemaggi, A. Sacchi, and G. Blandino, “Mutant p53: an oncogenic transcription factor,” Oncogene, vol. 26, no. 15, pp. 2212–2219, 2007.
- A. M. Goh, C. R. Coffill, and D. P. Lane, “The role of mutant p53 in human cancer,” Journal of Pathology, vol. 223, no. 2, pp. 116–126, 2011.
- N. C. Reich and A. J. Levine, “Growth regulation of a cellular tumour antigen, p53, in nontransformed cells,” Nature, vol. 308, no. 5955, pp. 199–201, 1984.
- J. C. Reed, J. D. Alpers, P. C. Nowell, and R. G. Hoover, “Sequential expression of protooncogenes during lectin-stimulated mitogenesis of normal human lymphocytes,” Proceedings of the National Academy of Sciences of the United States of America, vol. 83, no. 11, pp. 3982–3986, 1986.
- J. Mosner, T. Mummenbrauer, C. Bauer, G. Sczakiel, F. Grosse, and W. Deppert, “Negative feedback regulation of wild-type p53 biosynthesis,” EMBO Journal, vol. 14, no. 18, pp. 4442–4449, 1995.
- K. Boggs and D. Reisman, “Increased p53 transcription prior to DNA synthesis is regulated through a novel regulatory element within the p53 promoter,” Oncogene, vol. 25, no. 4, pp. 555–565, 2006.
- K. Boggs and D. Reisman, “C/EBPβ participates in regulating transcription of the p53 gene in response to mitogen stimulation,” Journal of Biological Chemistry, vol. 282, no. 11, pp. 7982–7990, 2007.
- D. Ginsberg, M. Oren, M. Yaniv, and J. Piette, “Protein-binding elements in the promoter region of the mouse p53 gene,” Oncogene, vol. 5, no. 9, pp. 1285–1290, 1990.
- P. F. Johnson, “Molecular stop signs: regulation of cell-cycle arrest by C/EBP transcription factors,” Journal of Cell Science, vol. 118, no. 12, pp. 2545–2555, 2005.
- D. P. Ramji and P. Foka, “CCAAT/enhancer-binding proteins: structure, function and regulation,” Biochemical Journal, vol. 365, no. 3, pp. 561–575, 2002.
- S. L. McKnight, “McBindall—a better name for CCAAT/enhancer binding proteins?” Cell, vol. 107, no. 3, pp. 259–261, 2001.
- E. M. Eaton, M. Hanlon, L. Bundy, and L. Sealy, “Characterization of C/EBPβ isoforms in normal versus neoplastic mammary epithelial cells,” Journal of Cellular Physiology, vol. 189, no. 1, pp. 91–105, 2001.
- P. Descombes, M. Chojkier, S. Lichtsteiner, E. Falvey, and U. Schibler, “LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein,” Genes and Development, vol. 4, no. 9, pp. 1541–1551, 1990.
- V. Ossipow, P. Descombes, and U. Schibler, “CCAAT/enhancer-binding protein mRNA is translated into multiple proteins with different transcription activation potentials,” Proceedings of the National Academy of Sciences of the United States of America, vol. 90, no. 17, pp. 8219–8223, 1993.
- A. Polson, P. Takahashi, and D. Reisman, “ChIP (chromatin immunoprecipitation) analysis demonstrates co-ordinated binding of two transcription factors to the promoter of the p53 tumour-suppressor gene,” Cell Biology International, vol. 34, no. 9, pp. 883–891, 2010.
- F. Schweisguth and J. W. Posakony, “Suppressor of Hairless, the Drosophila homolog of the mouse recombination signal-binding protein gene, controls sensory organ cell fates,” Cell, vol. 69, no. 7, pp. 1199–1212, 1992.
- H. Kato, Y. Taniguchi, H. Kurooka et al., “Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives,” Development, vol. 124, no. 20, pp. 4133–4141, 1997.
- F. Oswald, M. Winkler, Y. Cao et al., “RBP-Jκ/SHARP recruits CtIP/CtBP corepressors to silence notch target genes,” Molecular and Cellular Biology, vol. 25, no. 23, pp. 10379–10390, 2005.
- A. Robert-Moreno, L. Espinosa, J. L. de la Pompa, and A. Bigas, “RBPjkappa-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells,” Development, vol. 132, no. 5, pp. 1117–1126, 2005.
- L. Miele, “Notch signaling,” Clinical Cancer Research, vol. 12, article 1074e9, 2006.
- J. J. D. Hsieh and S. D. Hayward, “Masking of the CBF1/RBPJ(κ) transcriptional repression domain by Epstein-Barr virus EBNA2,” Science, vol. 268, no. 5210, pp. 560–563, 1995.
- I. Olave, D. Reinberg, and L. D. Vales, “The mammalian transcriptional repressor RBP (CBF1) targets TFIID and TFIAA to prevent activated transcription,” Genes and Development, vol. 12, no. 11, pp. 1621–1637, 1998.
- K. Boggs, B. Henderson, and D. Reisman, “RBP-Jκ binds to and represses transcription of the p53 tumor suppressor gene,” Cell Biology International, vol. 33, no. 3, pp. 318–324, 2009.
- P. Takahashi, A. Polson, and D. Reisman, “Elevated transcription of the p53 gene in early S-phase leads to a rapid DNA-damage response during S-phase of the cell cycle,” Apoptosis, vol. 16, no. 9, pp. 950–958, 2011.