Strategies to Identify Recognition Signals and Targets of SUMOylation

Table 1

SUMO/Sentrin specific proteases. SUSPs/SENPs implications and functions. Adapted from Wilkinson and Henley, 2010 [3].

Species	Name	Tissue expression	Localization	Preference	Processing	Deconjugation	Chain editing
S. cerevisiae	Upl1	NA	Nuclear periphery	NA	Yes	Yes	No
	Upl2	NA	Nucleoplasm	NA	No	No	Yes
Mammals	SENP1	Testes (high), pancreas, spleen, liver, ovaries, small intestine, thymus (low).	Nuclear pore and Nucleoplastic speckles	S1 > S2/3	Yes	Yes	No
	SENP2	ND	Nuclear pore	S2/3 > S1	Yes	Yes	No
	SENP3	ND	Nucleolus	S2/3	ND	Yes	No
	SENP5	ND	Nucleolus	S2/3	Yes	Yes	No
	SENP6	ND	Nucleoplasm	S2/3	No	No	Yes
	SENP7	Testes (high), pancreas, ovaries, colon, peripheral blood.	Nucleoplasm	S2/3	No	No	Yes