A Quantitative Structure-Activity Relationship and Molecular Modeling Study on a Series of Heteroaryl- and Heterocyclyl-Substituted Imidazo[1,2-a]Pyridine Derivatives Acting as Acid Pump Antagonists

Table 2

Some proposed compounds belonging to the series of Table 1 and their activities predicted from (1).

S. no.	R^6	R^3	R^4	π R3	GTCI	𝐼1	𝐼2	Log(1/IC50)
1			H	3.61	0.38	1	1	14.25
2			OH	3.16	0.41	1	1	13.83
3			H	2.82	0.43	1	1	12.80
4			OH	2.69	0.43	1	1	12.52
5			H	2.66	0.42	1	1	12.59
6			H	2.68	0.42	1	1	12.63
7			H	2.65	0.42	1	1	12.57
8			H	2.08	0.43	1	1	11.17
9			H	2.04	0.43	1	1	11.08
10			H	2.01	0.43	1	1	11.02
11			H	1.96	0.42	1	1	11.05
12			OH	1.66	0.42	1	1	10.39
13			H	2.32	0.44	1	1	11.56
14			H	2.14	0.46	1	1	10.88
15			OH	2.13	0.42	1	1	11.42
16			OH	1.69	0.43	1	1	10.31
17			OH	4.09	0.42	1	1	15.74