C-Lobe of Lactoferrin: The Whole Story of the Half-Molecule
Figure 8
Schematic diagram of complex of (a) C-lobe of lactoferrin (blue) with indomethacin (green), showing the accessible drug-binding site in between the two helices, α10 and α11. The α12 helix has been cleaved by proteinase K to make this site more accessible and (b) C-lobe of lactoferrin (blue) with indomethacin (green), with superimposed α12 helix (in red) from native bovine lactoferrin, which shows that this helix blocks the passage to the binding site.
