- About this Journal ·
- Abstracting and Indexing ·
- Aims and Scope ·
- Article Processing Charges ·
- Articles in Press ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
Biochemistry Research International
Volume 2013 (2013), Article ID 764262, 6 pages
Effects of Spirulina on Cyclophosphamide-Induced Ovarian Toxicity in Rats: Biochemical and Histomorphometric Evaluation of the Ovary
1Maltepe University School of Medicine, Department of Pathology, Maltepe, 34843 Istanbul, Turkey
2Maltepe University School of Medicine, Department of Urology, Maltepe, 34843 Istanbul, Turkey
3Maltepe University School of Medicine, Department of Obstetrics & Gynecology, Maltepe, 34843 Istanbul, Turkey
4Maltepe University School of Medicine, Department of Internal Medicine, Maltepe, 34843 Istanbul, Turkey
5Maltepe University School of Medicine, Department of General Surgery, Maltepe, 34843 Istanbul, Turkey
6Maltepe University School of Medicine, Department of Biochemistry, Maltepe, 34843 Istanbul, Turkey
Received 30 November 2012; Revised 22 March 2013; Accepted 10 April 2013
Academic Editor: Paul W. Doetsch
Copyright © 2013 Nese Arzu Yener et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- F. Tomao, G. P. Spinelli, P. B. Panici, L. Frati, and S. Tomao, “Ovarian function, reproduction and strategies for fertility preservation after breast cancer,” Critical Reviews in Oncology/Hematology, vol. 76, no. 1, pp. 1–12, 2010.
- S. J. Lee, L. R. Schover, A. H. Partridge et al., “American Society of Clinical Oncology recommendations on fertility preservation in cancer patients,” Journal of Clinical Oncology, vol. 24, no. 18, pp. 2917–2931, 2006.
- R. M. Chapman, “Effect of cytotoxic therapy on sexuality and gonadal function,” Seminars in Oncology, vol. 9, no. 1, pp. 84–94, 1982.
- M. E. Clowse, S. C. Copland, T. C. Hsieh et al., “Ovarian reserve diminished by oral cyclophosphamide therapy for granulomatosis with polyangiitis (Wegener's),” Arthritis Care & Research, vol. 63, no. 12, pp. 1777–1781, 2011.
- K. Shkolnik, A. Tadmor, S. Ben-Dor, N. Nevo, D. Galiani, and N. Dekel, “Reactive oxygen species are indispensable in ovulation,” Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 4, pp. 1462–1467, 2011.
- P. J. Devine, S. D. Perreault, and U. Luderer, “Roles of reactive oxygen species and antioxidants in ovarian toxicity,” Biology of Reproduction, vol. 86, no. 2, pp. 1–10, 2012.
- M. Tsai-Turton, B. T. Luong, Y. Tan, and U. Luderer, “Cyclophosphamide-induced apoptosis in COV434 human granulosa cells involves oxidative stress and glutathione depletion,” Toxicological Sciences, vol. 98, no. 1, pp. 216–230, 2007.
- J. Fujii, Y. Iuchi, and F. Okada, “Fundamental roles of reactive oxygen species and protective mechanisms in the female reproductive system,” Reproductive Biology and Endocrinology, vol. 3, p. 43, 2005.
- U. Isaoglu, M. Yilmaz, M. Calik et al., “Biochemical and histopathologic investigation of the protective effect of disulfiram in ischemia-induced ovarian damage,” Gynecological Endocrinology, vol. 28, no. 2, pp. 143–147, 2012.
- S. Bozkurt, D. C. Arikan, E. B. Kurutas et al., “Selenium has a protective effect on ischemia/reperfusion injury in a rat ovay model: biochemical and histopathologic evaluation,” Journal of Pediatric Surgery, vol. 47, no. 9, pp. 1735–1741, 2012.
- J. L. Tilly and K. I. Tilly, “Inhibitors of oxidative stress mimic the ability of follicle-stimulating hormone to suppress apoptosis in cultured rat ovarian follicles,” Endocrinology, vol. 136, no. 1, pp. 242–252, 1995.
- A. Belay, “The potential application of Spirulina (Arthrospira) as a nutritional and therapeutic supplement in health management,” Journal of the American Nutraceutical Association, vol. 5, no. 2, pp. 27–49, 2002.
- T. Karaca and N. Simsek, “Effects of spirulina on the number of ovary mast cells in lead-induced toxicity in rats,” Phytotherapy Research, vol. 21, no. 1, pp. 44–46, 2007.
- G. Chamorro-Cevallos, L. Garduño-Siciliano, B. L. Barrón, E. Madrigal-Bujaidar, D. E. Cruz-Vega, and N. Pages, “Chemoprotective effect of Spirulina (Arthrospira) against cyclophosphamide-induced mutagenicity in mice,” Food and Chemical Toxicology, vol. 46, no. 2, pp. 567–574, 2008.
- B. J. Davis and J. J. Heindel, “Ovarian toxicants: multiple mechanisms of action,” in Reproductive and Developmental Toxicology, K. S. Korach, Ed., pp. 373–395, Marcel Dekker, New York, NY, USA, 1998.
- D. Meirow, H. Lewis, D. Nugent, and M. Epstein, “Subclinical depletion of primordial follicular reserve in mice treated with cyclophosphamide: clinical importance and proposed accurate investigative tool,” Human Reproduction, vol. 14, no. 7, pp. 1903–1907, 1999.
- J. L. Tilly, “Ovarian follicle counts-not as simple as 1, 2, 3,” Reproductive Biology and Endocrinology, vol. 1, p. 11, 2003.
- Y. Xiang, J. Xu, L. Li et al., “Calorie restriction increases primordial follicle reserve in mature female chemotherapy-treated rats,” Gene, vol. 493, no. 1, pp. 77–82, 2012.
- E. S. Sills, M. M. Alper, and A. P. H. Walsh, “Ovarian reserve screening in infertility: practical applications and theoretical directions for research,” European Journal of Obstetrics Gynecology and Reproductive Biology, vol. 146, no. 1, pp. 30–36, 2009.
- S. K. Petrillo, P. Desmeules, T. Q. Truong, and P. J. Devine, “Detection of DNA damage in oocytes of small ovarian follicles following phosphoramide mustard exposures of cultured rodent ovaries in vitro,” Toxicology and Applied Pharmacology, vol. 253, no. 2, pp. 94–102, 2011.
- D. R. Plowchalk and D. R. Mattison, “Phosphoramide mustard is responsible for the ovarian toxicity of cyclophosphamide,” Toxicology and Applied Pharmacology, vol. 107, no. 3, pp. 472–481, 1991.
- P. Desmeules and P. J. Devine, “Characterizing the ovotoxicity of cyclophosphamide metabolites on cultured mouse ovaries,” Toxicological Sciences, vol. 90, no. 2, pp. 500–509, 2006.
- L. Luo, D. Z. Yang, Z. Wang, Q. X. Zhang, Y. Q. Mo, and N. DI, “Cyclophosphamide-induced ovarian damage and stem cell factor expression in rat ovaries,” Nan Fang Yi Ke Da Xue Xue Bao, vol. 27, no. 10, pp. 1476–1479, 2007.
- S. G. Lopez and U. Luderer, “Effects of cyclophosphamide and buthionine sulfoximine on ovarian glutathione and apoptosis,” Free Radical Biology and Medicine, vol. 36, no. 11, pp. 1366–1377, 2004.
- M. R. Hussein, “Apoptosis in the ovary: molecular mechanisms,” Human Reproduction Update, vol. 11, no. 2, pp. 162–178, 2005.
- D. L. Boone and B. K. Tsang, “Caspase-3 in the rat ovary: localization and possible role in follicular atresia and luteal regression,” Biology of Reproduction, vol. 58, no. 6, pp. 1533–1539, 1998.
- S. Y. Lee, J. Y. Lee, S. J. Oh, H. C. Kim, and S. K. Kim, “Expression of hepatic and ovarian antioxidant enzymes during estrous cycle in rats,” Toxicology Letters, vol. 212, no. 3, pp. 329–336, 2012.
- B. D. Lawenda, K. M. Kelly, E. J. Ladas, S. M. Sagar, A. Vickers, and J. B. Blumberg, “Should supplemental antioxidant administration be avoided during chemotherapy and radiation therapy?” Journal of the National Cancer Institute, vol. 100, no. 11, pp. 773–783, 2008.
- K. N. Prasad and W. C. Cole, “Antioxidants in cancer therapy,” Journal of Clinical Oncology, vol. 24, no. 6, pp. 8–9, 2006.