[Retracted] Exploring Drug Targets in Isoprenoid Biosynthetic Pathway for Plasmodium falciparum

Figure 1

The role of the apicoplast in production of isoprenoid precursors, IPP and DMAPP, which are exported into the cytoplasm and used to synthesize small molecule isoprenoids and prenylated proteins. P. falciparum is unable to synthesize isoprenoid precursors either due to inhibition of the biosynthetic pathway by fosmidomycin or loss of the apicoplast following doxycycline inhibition which can be chemically rescued by addition of exogenous IPP. The exogenous IPP enters the host cell through unknown membrane transporters and fulfills the missing biosynthetic function [7].