Cytotoxic Effects of Newly Synthesized Palladium(II) Complexes of Diethyldithiocarbamate on Gastrointestinal Cancer Cell Lines
Figure 4
Palladium complex induced cell cycle arrest. AGS, Kyse-30, and HepG2 cell lines were incubated with IC50 of the Pd complexes. After the incubation for 24 hrs, the cells were harvested and stained with DAPi, and DNA content was assessed by flow cytometry. The percentage of cells in each phase was plotted as a function of IC50 of the Pd complexes. The progression of AGS (a) and HepG2 (b) cell cycle was blocked in G2-M when treated with IC50 of three Pd complexes; hence, they stop Kyse-30 cell cycle progression in the S phase (c).
