Cytotoxic Effects of Newly Synthesized Palladium(II) Complexes of Diethyldithiocarbamate on Gastrointestinal Cancer Cell Lines
Table 1
IC50 (µg)* values of the complexes on AGS, Kyse-30, and HepG2 cell lines, as determined by MTT (24 and 48 hrs) assay. The cytotoxic activity of three novel Pd(II) complexes was significantly higher () in comparison with cisplatin.
Cell lines
AGS
Kyse-30
HepG2
24 h
48 h
Total IC50
24 h
48 h
Total IC50
24 h
48 h
Total IC50
Complex 1
0.74 ± 0.11
0.63 ± 0.12
0.68 ± 0.12
0.87 ± 0.11
0.89 ± 0.25
0.88 ± 0.18
1.00 ± 0.01
1.04 ± 0.30
1.02 ± 0.16
Complex 2
0.80 ± 0.04
0.75 ± 0.22
0.78 ± 0.13
1.02 ± 0.20
0.95 ± 0.31
0.98 ± 0.26
1.12 ± 0.10
1.23 ± 0.20
1.17 ± 0.15
Complex 3
1.48 ± 0.46
0.94 ± 0.16
1.2 ± 0.31
1.05 ± 0.23
1.06 ± 0.22
1.06 ± 0.23
1.30 ± 0.15
1.09 ± 0.07
1.19 ± 0.11
Cisplatin
4.40 ± 1.56
3.76 ± 0.3
4.08 ± 0.93
1.79 ± 0.30
2.00 ± 0.46
1.9 ± 0.38
2.07 ± 0.05
2.09 ± 0.15
2.079 ± 0.10
Mean values ± standard deviation from experiments.
