Cytotoxic Effects of Newly Synthesized Palladium(II) Complexes of Diethyldithiocarbamate on Gastrointestinal Cancer Cell Lines

Table 2

The Pd(II) induced cell cycle arrest. The cell cycle progression blockage was seen in G2-M after 24 hrs of treatment with the IC50 of the Pd(II) complexes.

	AGS			Kyse-30			HepG2
	G0-G1%	S%	G2M%	G0-G1%	S%	G2M%	G0-G1%	S%	G2M%
Control	53.85 ± 1.95	21.27 ± 3.50	24.88 ± 2.20	54.39 ± 1.32	16.6 ± 1.59	29.01 ± 1.83	55.97 ± 0.4795	16.35 ± 0.99	27.68 ± 1.86
Complex 1	50 ± 1.44	12.15 ± 0.59	37.84 ± 1.66^a	53.01 ± 3.48	23.92 ± 0.26^a	22.4 ± 3.16	52.04 ± 3.06	11.39 ± 4.84	36.57 ± 2.76^a
Complex 2	51.24 ± 4.65	9.29 ± 0.56	39.47 ± 4.1^a	49.98 ± 1.68	21.31 ± 2.13^a	28.70 ± 4.98	47.41 ± 4.2	16.68 ± 1.53	35.90 ± 0.97^a
Complex 3	52.85 ± 3.77	11.83 ± 6.95	35.31 ± 4.16^a	47.96 ± 7.65	25.17 ± 3.52^a	26.87 ± 4.13	46.64 ± 4.64	14.19 ± 2.20	39.18 ± 3.15^a

The data were pooled from three independent tests and were presented as mean ± STDEV; ^a<0.05.