Research Article
A Polymorphism in Hepatocyte Nuclear Factor 1 Alpha, rs7310409, Is Associated with Left Main Coronary Artery Disease
Table 1
Patient demographics and risk factors for CAD (LMCAD and MPCAD) (all subjects).
| | Variable | LMCADb () | MPCADc () | value | All CADd () |
| | Mean age, years | 62.24 (±8.66) | 60.14 (±8.96) | <0.001 | 60.84 (±8.91) | | Female, % | 67 (16.7) | 170 (21.1) | 0.065 | 237 (19.7) | | Mean BMIa, kg/m2 | 25.55 (±3.16) | 25.75 (±3.13) | 0.299 | 25.68 (±3.14) | | Family history of CAD, % | 21 (5.2) | 32 (4.0) | 0.323 | 53 (4.4) | | Previous smoker, % | 211 (52.5) | 422 (52.5) | 1.000 | 633 (52.5) | | Hypertension, % | 261 (64.9) | 530 (65.9) | 0.732 | 791 (65.6) | | Hyperlipidemia, % | 275 (68.4) | 573 (71.3) | 0.290 | 848 (70.4) | | Diabetes mellitus, % | 125 (31.1) | 271 (33.7) | 0.363 | 396 (32.8) | | Mean ejection fraction, % | 60.25 (±7.96) | 59.55 (±8.76) | 0.177 | 59.78 (±8.50) | | Disease territories, % | | | | | | 1-2 | 27 (6.7) | 99 (12.3) | 0.003 | 126 (10.4) | | 3 | 375 (93.3) | 705 (87.7) | 0.003 | 1080 (89.6) | | LMCAD, % | 402 (100) | 0 (0) | — | 402 (33.3) | | Anterior descending artery system, % | 386 (96.0) | 793 (98.6) | 0.004 | 1179 (97.8) | | Circumflex branch of left coronary artery system, % | 373 (92.8) | 744 (92.5) | 0.876 | 1117 (92.6) | | Right coronary artery system, % | 374 (93.0) | 751 (93.4) | 0.807 | 1125 (93.3) | | OPCABe/cCABGf | 209/193 | 438/366 | 0.414 | 647/559 |
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aBMI: body mass index; bLMCAD: left main coronary artery disease; cMPCAD: more peripheral coronary artery disease. Bold values are statistically significant (); dCAD: coronary artery disease; eOPCAB: off-pump coronary artery bypass grafting; fcCABG: conventional coronary artery bypass grafting.
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