Characterization of Protein Complexes and Subcomplexes in Protein-Protein Interaction Databases

Figure 1

Nested protein complexes from iRefIndex. (a) Group ID: 421, complex plot. Labels correspond to iRefIndex ROG IDs. (b) Group ID: 421, protein plot. Labels correspond to UniProt IDs; colors denote different complexes and multiple edges representing membership to multiple complexes. P01589: interleukin-2 receptor subunit alpha, P60568: interleukin-2, P31785: cytokine receptor common subunit gamma, and P14784: interleukin-2 receptor subunit beta. (c) Group ID: 570, complex plot. (d) Group ID: 570, protein plot. Q9NXR7: BRCA1-A complex subunit BRE, Q06609: DNA repair protein RAD51 homolog 1, P38398: breast cancer type 1 susceptibility protein, P04637: cellular tumor antigen p53, Q99728: BRCA1-associated RING domain protein 1, P46736: Lys-63-specific deubiquitinase BRCC36, and P51587: breast cancer type 2 susceptibility protein. Arrows indicate a subsumption relationship.

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