Modulatory Effects of Eschscholzia californica Alkaloids on Recombinant GABA_A Receptors

Figure 3

(a) (A) Electrospray ESI trace and (B) tandem MS/MS fragmentation pattern for selected ion m/z 354 corresponding to alkaloid protopine detected in a pharmacy capsule (300 mg) of E. californica (AMM 57426001) following alkaloid extraction and separation (Method A). (b) Electrospray ESI trace (A) and tandem MS/MS profile (B) for 6S,12S-neocaryachine-7-O-methyl ether N-metho salt detected in the same AMM 57426001 sample. Note that m/z 354 for this pavine alkaloid is practically identical to that of protopine; however, it gives quite different fragmentation pattern.

(a)

(b)