Ubiquitin Proteasome System in Stress and Disease
1Laboratory of Chromatin Structure and Functions, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow 119991, Russia
2Department of Biology, Technion – Israel Institute of Technology, Haifa 32000, Israel
3Department of Biochemistry and Molecular Biology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
4Department of Microbiology & Immunology, University of California, San Francisco, CA 94143-0414, USA
Ubiquitin Proteasome System in Stress and Disease
Description
Proteasome is an ATP-dependent multisubunit protease complex that is the major regulator of intracellular proteins turnover. It selectively degrades proteins modified by covalent attachment of polyubiquitin chains and some specific proteins without prior polyubiquitination. Among well-known proteasome substrates are regulatory proteins, for example, cyclins, transcription factors, and components of signal transduction pathways and proteins that have abnormal structure because of mutations in gene coding regions or transcription/translational errors, or action stress factors like heat shock and reactive oxygen species. No doubt, ubiquitin-proteasome system (UPS) is vital for normal cell function and its survival upon stress conditions. UPS dysfunction can contribute to or be a cause of severe human disorders like neurodegenerative diseases, cancers, muscle dystrophy, and so on.
We invite investigators to contribute original research articles and reviews that will further detail our understanding of molecular mechanisms of stress resistance and diseases with large contribution of UPS and describe new ways of identification and correction of UPS dysfunction. Potential topics include, but are not limited to:
- Stress- and disease-associated changes in substrate recognition by UPS
- Novel inhibitors or activators of UPS components
- Regulation of UPS biogenesis under nonphysiological conditions
- Modulation of UPS components activity by cellular and viral proteins
- Role of ubiquitin and ubiquitin-like modifiers in stress resistance and diseases
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