A Composite Synergistic Systems Model for Exploring the Efficacies of Different Chemotherapeutic Strategies in Cancer

Figure 1

Target site of different therapeutic strategies of the CSS model. In figure, 𝑐₁, 𝑐₂ and 𝑣𝑣 represent the drug-sensitive, drug-resistive, and MV cells, respectively, in VG model; 𝑆, 𝑅, and 𝑛 represent the drug sensitive, drug resistive cells, and microvasculature diameter, respectively, in FD model; and HSC and BM represent the pluripotent hematopoietic stem cell and bone marrow, respectively. In figure, direct arrows, dash dotted arrows, and dotted arrows represent direct, conditional, and indirect effects of drugs.