A Composite Synergistic Systems Model for Exploring the Efficacies of Different Chemotherapeutic Strategies in Cancer
Table 2
(a) States of drug strategy activation switches during different drug strategies. (b) States of activation switches for producing different effects during different drug strategies.
(a)
Switches
Free growth
MTD
MCT
AAG
MTD + HSC
0
1
0
0
0
0
0
1
0
0
0
0
0
1
0
0
0
0
0
1
0
0
0
0
1
(b)
Switches
Free growth
MTD
MCT
AAG
MTD + HSC
Condition
0
0
1
0
0
If immunity is being developed
0
0
1
0
0
If stem cell mobilization inhibition is developed
0
1
0
0
1
Depending on the cell number and drug present (in MTD or MTD + HSC condition) within the system
