Table 4: Sensitivity, specificity, predictive values, and diagnostic odds ratios using the highest values of all biomarkers within the first 24 hrs of ICU admission.

Sensitivity Specificity PPV NPV DOR (95% CI) CRP cut-off value 50 μg/mL 88% 23% 45% 71% 2.1 (0.6–7.3) PCT cut-off value 2 ng/mL 97% 80% 78% 97% 120.6 (14.4–1006) PCT cut-off value 10 ng/mL 66% 93% 88% 79% 26.1 (6.6–103.8) IL-6 cut-off value 50 pg/mL 91% 41% 53% 86% 6.7 (1.8–25.4) LBP cut-off value 30 μg/mL 53% 91% 81% 73% 11.3 (3.3–39.3)

Sensitivity: percentage of septic patients with positive test. Specificity: percentage of nonseptic patients with negative test. PPV (positive predictive value): percentage of test-positive patients with sepsis. NPV (negative predictive value): percentage of test-negative patients without sepsis. DOR (diagnostic odds ratio): [sensitivity/(1 − sensitivity)]/[(1 − specificity)/specificity]: the ratio of the odds of disease with a positive test relative to the odds of disease with a negative test.