Relative Tissue Factor Deficiency Attenuates Ventilator-Induced Coagulopathy but Does Not Protect against Ventilator-Induced Lung Injury in Mice

Table 1

Arterial blood gas analysis after 5 hours of mechanical ventilation.

	L𝑉𝑇		H𝑉𝑇
	TF^+/−	TF^+/+	TF^+/−	TF^+/+
pH	7.44 ± 0.08	7.45 ± 0.06	7.44 ± 0.07	7.44 ± 0.08
PaCO2 (mmHg)	35 ± 10	34 ± 8	33 ± 8	33 ± 8
PaO2 (mmHg)	165 ± 39	172 ± 48	236 ± 24^†	234 ± 26*
HCO3^− (mmol/L)	22.7 ± 2.9	22.6 ± 2.3	22.5 ± 2.1	21.1 ± 1.9
BE	−0.8 ± 2.7	−0.5 ± 0.7	0.8 ± 2.1	−2.1 ± 1.8

Data represent mean ± SD; L𝑉_𝑇: mice ventilated for 5 h with 𝑉_𝑇 of 7.5 mL/kg; H𝑉_𝑇: mice ventilated for 5 h with 𝑉_𝑇 of 15 mL/kg. TF^+/−: heterozygous TF knockout mice; TF^+/+: wild-type littermates; 𝑁=6 per group. *𝑃<0.05; ^†𝑃<0.01 versus L𝑉_𝑇 ventilation.