Impact of 6-Hour Sepsis Resuscitation Bundle Compliance on Hospital Mortality in a Saudi Hospital

Table 1

Patients characteristics and clinical data.

Variables	Historical group; (𝑛=99)	Post-intervention group; (𝑛=199)	𝑃 value
Age	68.6±18.3	65.0±20	0.13
Sex (male)	50 (51)	110 (55)	0.46
Septic shock	62 (63)	144 (72)	0.11
Sepsis screening
Mean arterial pressure (mmHg)	59.6±15.6	56.7±11.0	0.06
Heart rate (beats/min)	110±24.0	106±24.0	0.07
Respiratory rate (breaths/min)	26.0±7.6	26.1±7.7	0.57
Temperature (°C)	37.1±1.2	37.1±1.0	0.49
White-cell count (per mm^3)	15.6±10.1	14.5±8.6	0.32
Severity of illness
APACHE II score	21.6±7.4	21.2±7.0	0.22
Admission source
Emergency department	46 (46.4)	108 (54.2)	0.08
Wards	53 (53.5)	91 (45.7)	0.08
Co-morbid conditions
Diabetes mellitus	62 (62)	124 (62)	0.88
Hypertension	63 (63)	128 (64)	0.79
Chronic kidney disease	16 (16)	28 (14)	0.48
Malignancy	12 (12)	22 (11)	0.34
Source of infection
Urinary tract	21 (21)	36 (18)	0.36
Pneumonia	27 (28)	67 (34)	0.14
Abdomen	19 (19)	24 (12)	0.12
Soft tissue and skin	4 (4)	21 (11)	0.03
Others, with undetermined source	11 (11)	18 (9)	0.64
Mixed (>one source)	17 (17)	33 (16)	0.79
Other variables
Lactate (mmol/L)	3.9	3.5	0.09
Mechanical ventilation	54 (55)	90 (45)	0.11
Need for vasopressors	64 (67)	153 (76)	0.09
Mechanical ventilation days	5.8 ± 9.5	3.4 ± 6.7	0.01
Vasopressor days	4.4 ± 6.2	2.9 ± 5.1	0.03
CRRT	12 (12)	24 (12)	0.94

Results are expressed as Mean ± SD or 𝑛 (%), APACHE: acute physiology and chronic health evaluation, CRRT: continuous renal replacement therapy.