Review Article
ESBLs: A Clear and Present Danger?
| Bush-Jacoby-Medeiros Group | Molecular class (Ambler) | Preferred substrates | Representative enzymes | Resistance or susceptibility to β-lactamase inhibitors |
| 1 | C | Cephalosporins | AmpC | Resistant | 2b | A | Penicillins, Cephalosporins | TEM, SHV | Susceptible | 2be | A | Penicillins, extended-spectrum cephalosporins, monobactams | TEM, SHV | Susceptible | 2d | D | Penicillins, cloxacillin | OXA | Resistant | 2e | A | Cephalosporins | Inducible cephalosporinases from Proteus vulgaris | Susceptible | 2f | A | Penicillins, cephalosporins, carbapenems | NMC-A from Enterobacter cloacae | Resistant | 3 | B | Most β-lactams including carbapenems | L1 from Stenotrophomonas maltophilia | Resistant |
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Amended from original Bush-Jacoby-Medeiros classification scheme for bacterial β-lactamases.
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