Review Article

Optimization of Preload in Severe Sepsis and Septic Shock

Table 1

Accuracy of various parameters used to predict preload responsiveness [7, 10].

ParameterTechnologyAUC with 95% CI

PLR*Various methods of CO measurement0.95 (0.92–0.97)
PPVArterial BP waveform0.94 (0.93–0.95)
SVVArterial BP waveform analysis by proprietary algorithm0.84 (0.78–0.88)
LVEDAIEchocardiography0.64 (0.53–0.74)
GEDVThermodilution0.56 (0.37–0.67)
CVPCentral venous catheter0.55 (0.48–0.62)

PLR: passive leg raising, PPV: pulse pressure variation, SVV: stroke volume variation, LVEDAI: left ventricular end-diastolic area index, GEDV: global end-diastolic volume, CVP: central venous pressure, AUC: area under receiver operating characteristics curve.