Optimization of Preload in Severe Sepsis and Septic Shock
Table 1
Accuracy of various parameters used to predict preload responsiveness [7, 10].
Parameter
Technology
AUC with 95% CI
PLR*
Various methods of CO measurement
0.95 (0.92–0.97)
PPV
Arterial BP waveform
0.94 (0.93–0.95)
SVV
Arterial BP waveform analysis by proprietary algorithm
0.84 (0.78–0.88)
LVEDAI
Echocardiography
0.64 (0.53–0.74)
GEDV
Thermodilution
0.56 (0.37–0.67)
CVP
Central venous catheter
0.55 (0.48–0.62)
PLR: passive leg raising, PPV: pulse pressure variation, SVV: stroke volume variation, LVEDAI: left ventricular end-diastolic area index, GEDV: global end-diastolic volume, CVP: central venous pressure, AUC: area under receiver operating characteristics curve.