Optimization of Preload in Severe Sepsis and Septic Shock

Table 3

Critical components of the fluid challenge and one example of their application in a hypothetical patient (MAP of 65 mmHg and a CVP of 12 mmHg; two possible types of response are presented) [63].

Example	example 1			example 2
(1) Type of fluid: Ringer’s lactate	Baseline	+10 mins	+20 mins	Baseline	+10 mins	+20 mins
(2) Rate of infusion: 500 mL/30 mins
(3) Clinical end-points: MAP of 75 mmHg	MAP 65	MAP 70	MAP 75	MAP 65	MAP 67	MAP 60
(4) Pressure safety limits: CVP of 15 mmHg	CVP 12	CVP 13 Continue	CVP 14 Stop	CVP 12	CVP 14 Continue	CVP 15 Stop
	Successful fluid challenge			Unsuccessful fluid challenge

MAP: mean arterial pressure, CVP: central venous pressure, mins: minutes [63].