Role of New Biomarkers: Functional and Structural Damage

Table 2

NGAL for prediction of AKI in mixed ICU patients.

Reference	Publication; year	No. of AKI pts	Type of NGAL	Sensitivity; (%)	Specificity; (%)	AUC-ROC
Zappitelli et al. [25]*	2007	16/39	uNGAL	75.0	69.6	0.76
Wheeler et al. [26]*	2008	22/143	sNGAL	86.4	38.8	0.68
Makris et al. [27]	2009	7/31	uNGAL	85.7	70.8	0.90
Siew et al. [28]	2009	86/451	uNGAL	60.0	80.0	0.71
Little et al. [29]	2009	161/604	uNGAL; pNGAL	43.0; 64.0	90.0; 90.0	0.84; 0.83
Cruz et al. [30]	2010	15/301	pNGAL	73.4	80.6	0.78
Shapiro et al. [31]	2010	13/558	pNGAL	78.0	80.0	0.84
Mårtensson et al. [32]	2010	18/45	uNGAL; pNGAL	71.0; 83.0	100.0; 86.0	0.86; 0.67
Constantin et al. [33]	2010	52/88	pNGAL	82.7	97.2	0.93
de Geus et al. [34]	2011	171/632	uNGAL; pNGAL	89.0; 82.0	70.0; 70.0	0.80; 0.77
Royakkers et al. [35]	2012	83/140	uNGAL; sNGAL	—; —	—; —	0.48; 0.53

*Pediatric population, uNGAL: urine NGAL, pNGAL: plasma NGAL, sNGAL: serum NGAL, and AUC-ROC: area under the receiver-operating characteristic curve, —: not mentioned by the authors.